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Tue, 27 Jun 1995 22:23:04 -0400 |
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There is an excellent review of phenothiazines (stelazine is one of that
group of antipsychotics) by McElhatton P. The use of phenothiazines
during pregnancy and lactation. Reproductive Toxicology, 1992, Vol.6,
pp.475-90. They cite case reports mostly with other phenothiazines such
as chlorpromazine and haloperidol, where the levels in breast milk were
negligible and no adverse effects were noted. They also note that in
none of the follow-up studies (some up to 10 years of age) of children
exposed during pregnancy or breastfeeding were any physical or mental
developmental problems noted. They caution, however, that there are
really not enough data and that the potential for accumulation of these
drugs exists. The AAP lists these as "use with caution" due to unknown
long-term effects. Whenever drugs of this type are used during
breastfeeding, the baby needs to be watched for sedation, lethargy,
irritability or changes in feeding or sleeping patterns. Another
possible action is to check levels in mother's milk and draw blood levels
on the baby if the milk contains detectable levels. Of course, when
possible, it is best to dose the drug immediately after a feeding,
preferably prior to baby's longest sleep times. Hope this helps. If you
want a copy of this article, e-mail me. Alicia. [log in to unmask]
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