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Date: | Thu, 30 Dec 1999 10:20:10 -0500 |
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To : Belinda
Re : Glatiramer
The below is from my "Red Book Updates" a free email update program that I
have just begun. You can register for these on either of my web pages.
http://www.perinatalpub.com
http://neonatal.ttuhsc.edu/lact/
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#3 Glatiramer ( Copaxone)
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Tradename : Copaxone
Uses : Relapsing multiple sclerosis.
AAP : Not reviewed.
Glatiramer is a synthetic polypeptide indicated for the treatment of
relapsing, remitting multiple sclerosis. Glatiramer is a mixture of random
polymers of four amino acids, L-alanine, L-glutamic acid, L-lysine, and L-
tyrosine. Its molecular weight ranges from 4,700 to 13,000 daltons which
would reduce its ability to enter milk. It is antigenically similar to
myelin basic protein , a natural component of the myelin sheath of neurons.
No data is available on its transfer into human milk, but it is unlikely. If
ingested orally, it would likely be depolymerized into individual amino
acids, so toxicity is unlikely.
Oral Bioavail= unknown, but probably nil
T1/2 = unknown
Protein binding = unknown
Pediatric Concerns: None thus far
Pregnancy Risk Category: B
Regards
Tom Hale, Ph.D.
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