" So to all intents and purposes, in "field relevant conditions" (not a test tube, not what Casida does) it is IRREVERSIBLE BINDING."

It makes zero difference if there is anything else present to compete for the binding site.  To be irreversible binding MUST be via covalent bonds, which would be highly unusual.  There is no way to get the dissociation activation energy barrier high enough other than covalent bonds.  Any binding via bonds with significant ionic character WILL be reversible for the simple reason that thermodynamics demands it to be reversible.  Living organisms can not avoid the laws of thermodynamics.  Why does a neonic form covalent binding bonds when nicotine itself forms ionic binding bonds if the claim of irreversible binding  of neonics is correct?

Dick

" Any discovery made by the human mind can be explained in its essentials to the curious learner."  Professor Benjamin Schumacher talking about teaching quantum mechanics to non scientists.   "For every complex problem there is a solution which is simple, neat and wrong."  H. L. Mencken

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