"So that means that the metabolization if it is proceeding by "half life" is
a curve approaching (but never reaching) zero and the amounts remaining
could be the amounts that are bound to the receptor."


Understanding that,  but disagreeing a bit with the point.,  so they never
reach zero  so what??  As long as they fall behold a threshold of harm they
could be considered gone.   Take  Cocaine  residues remain in the hair on
the body for months after any real effect is gone.  For all purposes they
are inert.   We say the same for alcohol.  Common theory is it kills some
brain cells.  But in the scheme of things   small doses are quickly cleared.


Which brings me back to my original question.  While it quite interesting to
listen to the debate,  I think most of us are way below the level your
talking at.  So what I want to know is at the dumbed down level,  so what??
Are we saying that a single part per billion of  a neonic alters the brain
of the bee and its no longer able to function at full level in the hive?  Or
that after a few hours of a large dose its quite cleared?  

The debate is interesting,  no doubt.  But what are the real world
implications here??

Truth on the ground is showing a great improvement over the options,  and
yet we are in the dark debating what appears to be to my mind, fly poop in
pepper.....


Enlighten me why I should care??
Charles

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