Re: genetic basis of insecticide resistance

Detoxification of pyrethroid in insects is mainly accomplished by
monooxygenases, also called P450 enzymes. Over expression of
one or more of these P450 genes has been associated with pyrethroid
resistance in house flies [9], mosquitoes [10,11] and many other insects.

Several genes related to pyrethroid resistance
in pathways such as cellular and molecular metabolism,
signal transduction, vesicular and molecular transport, protein biosynthesis,
ubiquitination, and neuronal survival have been detected
by PCR hybridization and cDNA microarray technique [13].

It has been shown that insect detoxification of pyrethriod compound
is a multicellular and network function rather than the
function of a single enzyme.

Pesticide Biochemistry and Physiology 96 (2010) 1–7

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