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Subject:
paroxetine (Paxil)
From:
newman <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Fri, 24 Oct 1997 15:11:39 -0500
Content-Type:
text/plain
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text/plain (11 lines) 
Who said paroxetine is not recommended during breastfeeding?  The PDR?
We now know that paroxetine is extremely highly protein bound (>99%).
We also know that it has a high volume of distribution.  Less than 1% of
the total paroxetine in the mother's body is in her blood, and it is the
blood levels which determine how much gets excreted into the milk.

Sertraline (Zoloft) is a good choice as well.  (See Hale, see New
England Journal, 1997, April 17, letter describing study).

Jack Newman, MD, FRCPC

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