Metformin works by increasing the number of muscle and       adipocyte 
(fat cell) insulin receptors and the attraction for       the receptor. 
It does not increase insulin secretion, it only       increases insulin 
sensitivity. Therefore, metformin is not       associated with causing 
hypoglycemia. This activity reduces       insulin levels by increasing 
the sensitivity of peripheral       tissues to the effects of insulin by
 rejuvenating the       response, and restoring glucose and insulin to 
younger       physiological levels that may cause weight loss and most  
     certainly a decrease in the body's total fat content. Weight gain is a common side effect of risperidone. 
 Weight gain with risperidone occurs in up to 5 percent of people. While a
 small amount of weight gain (about one pound) is typical during 
treatment with risperidone, some people can gain very large amounts of 
weight while taking the medication. This weight gain is thought to 
increase the risk of diabetes
 or other health problems.  Now, connect the two.The two drugs seem to have opposite effects on the same metabolic system(s).



Frank J. Nice, RPh, DPA, CPHP
  		 	   		  
             ***********************************************

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