To : Lori
Re : Taxol

We do not know how much, if any, Taxol enters milk.  However, it does have a
rather long half-life of 52 hours, and its volume of distribution is huge,
suggesting that it might be stored in peripheral compartments and released
over many days of time, thus it could produce low and sustained milk levels.

On the other hand, its molecular weight is large and its plasma levels
rather low, which would suggest its ability to enter milk would be low.

So I cannot really suggest that it is safe to breastfeed after using this
drug.  If the mom wanted to pump and dump for 10 days, then it would
probably be safe, but I'm not really sure of this.  Drugs with huge Volumes
of Distribution tend to leach out of tissues for long periods.

We just don't have any set answer for this situation. Does the benefit of
breastfeeding outweight the risk of this dangerous drug.   Its questionable.

Sorry.

Tom Hale, PH.D.

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