Hi Angie

Gadodiamide is used in children at the same dose than in adults : 0,1
mmol/kg.
Pass very few in milk : less than 1% of maternal dose. Seems unlikely to
pose problems.
If the mother is 60 kg and so get 6 mmol, 1% is 0,06 mmol received by the
baby. If the baby is 4 kg, that means 0,015 mmol/kg...

Kindly
Françoise Railhet
Manager of the LLL France Medical Associates Program
[log in to unmask]


Kubik-Huch RA, Gottstein-Aalame NM, Frenzel T, et al. Excretion of
gadopentetate dimeglumine into human breast milk during lactation. Radiology
2000; 216:555- 558.
Niendorf HP, Haustein J, Cornelius I, Alhassan A, Clauss W. Safety of
gadolinium-DTPA: extended clinical experience. Magn Reson Med 1991;
22:222-228.
 Marti-Bonmati L, Vega T, Benito C, et al. Safety and efficacy of Omniscan
(gadodiamide injection) at 0.1 mmol/kg for MRI in infants younger than 6
months of age: phase III open multicenter study. Invest Radiol 2000;
35:141-147.
 Rubin DL, Falk KL, Sperling MJ, et al. A multicenter clinical trial of
Gadolite oral suspension as a contrast agent for MRI. J Magn Reson Imaging
1997; 7:865-872.
Kaminsky S, Laniado M, Gogoll M, Kornmesser W, Clauss W, Felix R. Oral
contrast media for the magnetic resonance tomography of the abdomen: a
clinical trial of the tolerance for gadolinium-DTPA. Rofo Fortschr Geb
Rontgenstr Neuen Bildgeb Verfahr 1992; 156:17-23.
 Rofsky NM, Weinreb JC, Litt AW. Quantitative analysis of gadopentetate
dimeglumine excreted in breast milk. J Magn Reson Imaging 1993; 3:131-132.
 Schmiedl UP, Maravilla KR, Gerlach R, Dowling C. Excretion of gadopentetate
dimeglumine in human breast milk. AJR Am J Roentgenol 1990; 154:1305-1306.

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