> i am writing to see if anyone might know of any info out there at all that  a 
> baby born w/ hydronephrosis who is exclusively breastfed need not be put on  
> antibiotics. i am writing on behalf of myself this particular time, but in my  
> work as a bfing volunteer for a large hospital here (detroit area) i have  
> actually worked w/ several moms whose babies were diagnosed w/ this issue... > 
> ...oddly enough, even more than the thought of prenatal surgery in the event  
> the problem worsens during the remainder of the pgc (22 wks now) or the thought  
> of my 2 yr old having kidney surgery, the thought of antibiotics from birth  
> until 2 just horrifies me 



In addition to agreeing with Rachel's response, I'd be asking the docs for evidence-based lit to support their recommendation for prophylactic vs. symptom-related use of antibiotics vis-a vis severity of problem for specific infant and risk for development of antibiotic sensitivities and/or resistance. Found some refs re: BF/human milk and UTI or human milk general immunology with probably/potential effect on urinary tract...

Mårild S, Hansson S, Jodal U, Odén A & K Svedberg K (2004). Protective effect of breastfeeding against urinary tract infection. Acta Paediatr, 93(2), 164-168. Accessed http://www.cirp.org/library/disease/UTI/marild4/; abstract accessed PubMed 
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15046267&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum on 11 June, 2007.

Hanson LA (2004). Protective effects of breastfeeding against urinary tract infection. Acta Paediatr, 93(2), 154-6. Abstract accessed PubMed http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15046263&dopt=Abstract on 11 June, 2007.

Chaturvedi P, et al (2001). Fucosylated human milk oligosaccharides vary between individuals and over the course of lactation. Glycobiology, 11(5), 365-372. Accessed http://glycob.oxfordjournals.org/cgi/content/full/11/5/365#CWE044TI on 11 June, 2007.

Schanler R (2000). Overview: The clinical perspective. J Nutr, 130:417S-419S. Accessed http://jn.nutrition.org/cgi/content/full/130/2/417S on 11 June, 2007. 

Schroten H, et al. (1998). Fab-independent antiadhesion effects of secretory immunoglobulin A on S-fimbriated Escherichia coli are mediated by sialyloligosaccharides. Infection & Immunity, 66(8), 3971-3973. Accessed http://iai.asm.org/cgi/content/full/66/8/3971 on 11 June, 2007.

Mansour L & Mansour A (1993). Breast feeding protects infants against urinary tract infection. New Egypt J Med, 8(2):463-464. Abstract accessed PubMed http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12320842&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus on 11 June, 2007.

Pisacane A, Graziano L, Mazzarella G, Scarpellino B & Zona G (1992). Breast-feeding and urinary tract infection. J Pediatr, 120, 87-89. Accessed http://www.cirp.org/library/disease/UTI/pisacane1992/; abstract accessed PubMed http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1731031&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus on 11 June, 2007.

Hutchens TW, J F Henry JF & Yip TT (1991). Structurally intact (78-kDa) forms of maternal lactoferrin purified from urine of preterm infants fed human milk: identification of a trypsin-like proteolytic cleavage event in vivo that does not result in fragment dissociation. Proc Natl Acad Sci USA, 88(8), 2994–2998. Accessed http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=51370&blobtype=pdf on 11 June, 2007.

Goldman AS, Garza C, Schanler RJ & RM Goldblum RM (1990). Molecular forms of lactoferrin in stool and urine from infants fed human milk. Pediatr Res, 27(3):252-255. Abstract accessed http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=2320391&dopt=Citation on 11 June, 2007.

Coppa GV, et al (1990). Preliminary study of breastfeeding and bacterial adhesion to uroepithelial cells. Lancet, 335(8689), 569-571. Abstract accessed PubMed http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1968576&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 11 June, 2007.

Goldblum RM, Schanler RJ, Garza C & Goldman AS (1989). Human milk feeding enhances the urinary excretion of immunologic factors in low birth weight infants. (1989). Pediatr Res, 25(2), 184-188. Abstract accessed http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=2919134&dopt=Citation on 11 June, 2007.


See also: Newman J. How human milk protects newborns. Accessed http://www.promom.org/bf_info/sci_am.htm on 11 June, 2007.

Check Abstracts in Journal of the American Academy of Nurse Practitioners 11 (2), 83–85 (Feb 1999). (Found ref to BF as re: infant UTI but couldn’t find text)

Good luck!

Karen G

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