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Eric;
Yes, it had occurred to me. One consideration is a point mutation in
a large protein like Hemoglobin might be stretching visitors
attention or willingness to spend time at an exhibit.
Martin
>
>
>Hello Martin,
>
>Sounds interesting. You may have thought of this already, but what about
>asking visitors to listen for mutations by comparing two sequences being
>played simultaneously?
>
>-Eric
>
>
>
>*****************************************
>Eric Yuan
>Exhibit Developer
>Children's Museum of Portsmouth
>280 Marcy Street
>Portsmouth, NH 03801
>(603) 436-3853
>www.childrens-museum.org
>*****************************************
>
>
>
>-----Original Message-----
>From: martin weiss [mailto:[log in to unmask]]
>Sent: Wednesday, May 09, 2007 11:25 AM
>To: [log in to unmask]
>Subject: [ISEN] Science and Music
>
>ISEN-ASTC-L is a service of the Association of Science-Technology Centers
>Incorporated, a worldwide network of science museums and related
>institutions.
>****************************************************************************
>*
>
> This article
>(http://www.nature.com/news/2007/070430/full/070430-7.html) and the
>gene2music site
>(http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/examples.html)
>seem to expand on the science song discussion we had earlier.
>Unfortunately the interface to create music from gene sequence is not
>easy or intuitive However, they do provide examples of music created
>from protein sequence data
>(http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/examples.html)
>
> From the Summary of the project:
>
>The primary goal of this work is to convert genome-encoded protein
>sequences into musical notes in order to hear auditory protein
>patterns. Although there have been previous efforts to do this, one
>of the main problems has involved the large jumps between consecutive
>notes in a 20 note range (2.5 octaves) that results from a one-to-one
>amino acid-to-musical note assignment. Some other concerns include
>assigning rhythm, dynamics, and accompaniment according to the
>characteristics of the protein sequence.
>We derived a reduced 13 base note range according to hydrophobicity
>and pairing of similar amino acids. The amino acid pairs were
>differentiated using variants of three-note chords, namely the root
>position and first inversion chords. A rhythm has been encoded into
>the musical sequence according to the organism's codon distribution
>used in the genome-encoded protein sequence. Such a designation
>allows each amino acid to be represented by different note durations.
>The result is a set of rules that produces musical compositions that
>can be applied to any protein sequence [1]. As an example, we have
>used a prototype human protein, Thymidylate Synthase A (ThyA). A
>detailed description of our coding assignment can be found in the
>Project Evolution.
>
>In addition to the primary goal, we also aim to use this conversion
>to help make protein sequences more approachable and tangible for the
>general public and children. The project also opens opportunities for
>visually impaired scientists to access protein sequences more
>readily. We show and allow one to listen to examples of several
>proteins translated into music by these methods and also provide the
>opportunity for others to convert their own gene of interest using
>our GENE2MUSIC program.
>
>Martin
>--
>Martin Weiss, Ph.D
>Vice President, Science
>New York Hall of Science
>47-01 111 th Street
>Corona, New York 11368
>718 699 0005 x 356
>
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>More information about the Informal Science Education Network and the
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>
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--
Martin Weiss, Ph.D
Vice President, Science
New York Hall of Science
47-01 111 th Street
Corona, New York 11368
718 699 0005 x 356
***********************************************************************
More information about the Informal Science Education Network and the
Association of Science-Technology Centers may be found at http://www.astc.org.
The ISEN-ASTC-L email list is powered by LISTSERVR software from L-Soft. To learn more, visit
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