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Charley;
Thanks for the note. I completely forgot about your exhibit. I guess
this is an opportunity for visitors to the web to do the activity at
home.
Martin
>
>Martin,
>
>FYI: You should be aware that we made an exhibit called musical
>mutants that was on the floor for about 10 years. It basically
>provided comparative DNA gene sequences, converted to amino acid
>sequences and musical notes, so that visitors could do comparisons
>between various sequences. We used Thymidylate Synthase as one of
>the sequences, and F1-ATPase (?), hemoglobin, and one other. It was
>a noisy, popular, engaging exhibit, and understanding varied with
>prior knowledge and experience.
>C
>On May 9, 2007, at 8:25 AM, martin weiss wrote:
>
>>ISEN-ASTC-L is a service of the Association of Science-Technology Centers
>>Incorporated, a worldwide network of science museums and related
>>institutions.
>>*****************************************************************************
>>
>> This article
>>(http://www.nature.com/news/2007/070430/full/070430-7.html) and the
>>gene2music site
>>(http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/examples.html)
>>seem to expand on the science song discussion we had earlier.
>>Unfortunately the interface to create music from gene sequence is
>>not easy or intuitive However, they do provide examples of music
>>created from protein sequence data
>>(http://www.mimg.ucla.edu/faculty/miller_jh/gene2music/examples.html)
>>
>> From the Summary of the project:
>>
>>The primary goal of this work is to convert genome-encoded protein
>>sequences into musical notes in order to hear auditory protein
>>patterns. Although there have been previous efforts to do this, one
>>of the main problems has involved the large jumps between
>>consecutive notes in a 20 note range (2.5 octaves) that results
>>from a one-to-one amino acid-to-musical note assignment. Some other
>>concerns include assigning rhythm, dynamics, and accompaniment
>>according to the characteristics of the protein sequence.
>>We derived a reduced 13 base note range according to hydrophobicity
>>and pairing of similar amino acids. The amino acid pairs were
>>differentiated using variants of three-note chords, namely the root
>>position and first inversion chords. A rhythm has been encoded into
>>the musical sequence according to the organism's codon distribution
>>used in the genome-encoded protein sequence. Such a designation
>>allows each amino acid to be represented by different note
>>durations. The result is a set of rules that produces musical
>>compositions that can be applied to any protein sequence [1]. As an
>>example, we have used a prototype human protein, Thymidylate
>>Synthase A (ThyA). A detailed description of our coding assignment
>>can be found in the Project Evolution.
>>
>>In addition to the primary goal, we also aim to use this conversion
>>to help make protein sequences more approachable and tangible for
>>the general public and children. The project also opens
>>opportunities for visually impaired scientists to access protein
>>sequences more readily. We show and allow one to listen to examples
>>of several proteins translated into music by these methods and also
>>provide the opportunity for others to convert their own gene of
>>interest using our GENE2MUSIC program.
>>
>>Martin
>>--
>>Martin Weiss, Ph.D
>>Vice President, Science
>>New York Hall of Science
>>47-01 111 th Street
>>Corona, New York 11368
>>718 699 0005 x 356
>>
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>
>Charles Carlson
>Director of Life Sciences
>exploratorium
>3601 Lyon St.
>San Francisco, CA 94123
>[log in to unmask]
>Tel: 415-561-0319
>Fax: 415-561-0370
>
>
>
>***********************************************************************
>More information about the Informal Science Education Network and the
>Association of Science-Technology Centers may be found at http://www.astc.org.
>
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--
Martin Weiss, Ph.D
Vice President, Science
New York Hall of Science
47-01 111 th Street
Corona, New York 11368
718 699 0005 x 356
***********************************************************************
More information about the Informal Science Education Network and the
Association of Science-Technology Centers may be found at http://www.astc.org.
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