> Genetic variability is a defining characteristic of virus the success of the swarm as a whole. The concept of defining a virus by its variability has been explored theoretically and experimentally within the quasispecies framework, with obvious parallels to population genetics in higher organisms. Most of the variation within a quasispecies is generated by the RNA polymerase, primarily through faulty incorporation of nucleotides and secondarily through recombination with other viruses (or even host RNAs), by switching templates during replication. Sometimes several major variants can be detected within a stable quasispecies, each with its own swarm of mutants, as well as recombinants between the variants

Joachim R. de Miranda, Elke Genersch. 2010. Deformed wing virus.

Peter Loring Borst
Ithaca  NY USA
peterloringborst.com
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