In doing research for my ABJ article on nosema, I found the following

Nosema disease is an infectious disease of adult
honeybees caused by the protozoan Nosema apis.
It is widespread, and under favorable conditions may
cause extensive losses of adult workers and queens in
the winter or spring. Attempts to control it with
antibiotics, sulfa drugs, arsenicals, and anti protozoan
agents have so far proved unsuccessful, although
it was recently reported that sulphaquinoxaline
(0.2%) lowered the percentage of dead infected
bees in cages by about 35%: however, one
third of the dead bees were still infected. In view of
these failures to control the disease, the announcement
of the striking amebicidal action of a new antibiotic,
fumagillin, aroused great interest. Accordingly,
some of this material was obtained (through the
courtesy of the Upjohn Company) and tested against
N. apis infections.

Control of Nosema Disease of Honeybees with Fumagillin
H. Katznelson and C. A. Jamieson
Science, New Series, Vol. 115, No. 2977 (Jan. 18, 1952), pp. 70-71

In the same issue

The antibiotics now used in the treatment of amebiasis
are believed to act primarily on the necessary
bacterial associates of the amebae, thereby indirectly
affecting the survival of the parasite. Recently
Hanson and Eble have reported a new antibiotic,
fumagillin, which has little antibacterial and antifungal
activity. Subsequent in vitro experiments and
animal studies by McCowen et al. have shown
this antibiotic to have marked amebicidal activity.

The Treatment of Amebiasis with Fumagillin
John H. Killough, Gordon B. Magill, and Richard C. Smith


Meanwhile, Free Patents Online reports

Compositions and methods for reducing susceptibility and enhancing tolerance to Nosema disease (Nosemosis) using RNA interference technology, and more particularly, prevention and treatment of Nosema infections in honeybees by feeding of Nosema-specific dsRNA.

Inventors:
Paldi, Nitzan (Moshav Bar Giora, IL)	
Glick, Eitan (Nes Ziona, IL)	
Application Number:
13/318636
Publication Date:
03/01/2012
Filing Date:
05/05/2010

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