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Subject:
Re: the difference between nicotinoids and neonicotinoids
From:
Mark Burlingame <[log in to unmask]>
Reply To:
Informed Discussion of Beekeeping Issues and Bee Biology <[log in to unmask]>
Date:
Wed, 27 Mar 2013 17:08:33 -0400
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>All neuronal, and neuromuscular, receptors cause excitation or inhibition postsynaptically.  This is their FUNCTION and >it is independent of their receptor binding AFFINITY.

This is missleading, activation regardless of the induced effect, still requires some baseline binding affinity and receptor occupancy.  This is determined by the absolute binding energy of the ligand to the receptor and the local concentration of the ligand.   Affinity is not activation.  

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