I saw the original paper when it first came out. I am still trying to get it translated:

> The essence of the Druckrey–Küpfmüller equation dtn = constant (where d = daily dose and t = exposure time-to-effect, with n > 1) for chemical carcinogens is that the total dose required to produce the same effect decreases with decreasing exposure levels, even though the exposure times required to produce the same effect increase with decreasing exposure levels. Druckrey and Küpfmüller inferred that if both receptor binding and the effect are irreversible, exposure time would reinforce the effect. The Druckrey–Küpfmüller equation explains why toxicity may occur after prolonged exposure to very low toxicant levels.

"The significance of the Druckrey–Küpfmüller equation", etc. by Henk A.Tennekes


Of course, it explains "why toxicity may occur" but they certainly didn't do anything but math in this study.


PLB

             ***********************************************
The BEE-L mailing list is powered by L-Soft's renowned
LISTSERV(R) list management software.  For more information, go to:
http://www.lsoft.com/LISTSERV-powered.html

Guidelines for posting to BEE-L can be found at:
http://honeybeeworld.com/bee-l/guidelines.htm