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Tue, 21 Nov 1995 18:31:27 -0600 |
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To Kathleen Bruce:
Kefzol(cefazolin) is a cephalosporin antibiotic. It will pass into milk to
a limited degree and probably be destroyed in the infants GI tract.
Milk:Plasma ratio = 0.02. Observe for a little diarrhea at most.
Dilaudid(hydromorphone) is a morphine derivative and is about 7 times as
potent as morphine, although the dose is correspondingly less. . Dilaudid
peak is 0.5 -1.0 hrs, Half-life is 2-3 hrs. Only trace amounts of
morphine ever appear in milk. Suggest waiting a few hours after
administration. Observe infant for sedation, constipation, decreased
respiration.
Toradol(Ketorolac) is a classic NSAID used frequently as a substitute for
opiate analgesics. Following a maternal dose of 40 mg/day, the infant would
receive about 3-7 ug of ketorolac per day, a dose clinically
insignificant(less than 0.4% of the dose).
Tom Hale
PS
And Kathleen, this wasn't in "Briggs" !!!
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T.W. Hale, Ph.D.
Associate Professor of Pediatrics
Texas Tech University School of Medicine
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