Guess who's trawling the literature today...
Anyway, I came across this study (see below). It's interesting because it shows that breastmilk-fed, VLBW-premies infants show less oxidative DNA damage (measure using urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion) than formula fed infants (commercial form or pretermform). The mean gestational age for the breastmilk group (n=15) was 29.2 versus 28.7 for the formula group (n=14). This study attracted my attention because of the recent posts about bm loosing it's antioxidative powers after +48hrs storage. It's a shame this study doesn't have data to show how long / conditions that expressed bm was subjected to before being given to these infants???
But is does show that there is an opening for a good study!
groetjes
Sara Bernard BSc
The Netherlands
http://fn.bmjjournals.com/cgi/content/abstract/89/2/F136
Archives of Disease in Childhood Fetal and Neonatal Edition 2004;89:F136
Suppressive effects of breast milk on oxidative DNA damage in very low birthweight infants
H Shoji, T Shimizu, K Shinohara, S Oguchi, S Shiga and Y Yamashiro
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan
Correspondence to:
Dr Shimizu
Department of Pediatrics, Juntendo University, School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; [log in to unmask]
Background: Human milk contains many kinds of antioxidant and is considered to prevent diseases mediated by oxygen free radicals in very low birthweight (VLBW) infants.
Aims: To examine the antioxidant effects of breast milk in VLBW infants by determining urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, which is known to be a non-invasive marker for in vivo oxidative DNA damage.
Methods: Urinary 8-OHdG concentrations were measured in 15 breast fed and 14 formula fed VLBW infants at 2, 7, 14, and 28 days of age.
Results: Urinary 8-OHdG excretion at 14 and 28 days of age was significantly lower than at 2 and 7 days of age in the breast fed group, and significantly lower than in the formula fed group.
Conclusion: This is the first direct evidence of the antioxidant action of human milk in VLBW infants.
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