Unfortunately, it would seem that Candida is becoming more and more resistant to fluconazole. I am now routinely giving 100 mg twice daily for *at least* two weeks. Even then, it may take a week for the mother to *start* feeling better and much longer for the pain to disappear. I have treated several mothers 5 or 6 weeks (until one full week pain free). However, they can often start feeling better within a day or two. Jack Newman, MD, FRCPC