ate: Thu, 25 Jan 1996 05:30:20 -0800 From: Denise Parker <[log in to unmask]> Subject: Motilium(domperidone) To Denise: Motilium* Generic = DOMPERIDONE Category = Antiemetic, stimulates lactation Domperidone(Motilium) is an investigational drug in the USA, and is not currently released for sale. It blocks peripheral dopamine receptors in the GI wall and in the CTZ(nausea center) in the brain and is currently used in Canada as an antiemetic. Because it does not enter the brain compartment, it has few CNS effects. It also is known to produce significant increases in prolactin levels and has proven useful as a galactagogue. Clinical trials are currently underway. AHL= 2-4 hrs. M/P= PB= PHL= PK = 30 min.(IM) Tom Hale * From "Medications and Mothers' Milk" 1995