On 12/05/2007, at 23:16, laurie wheeler wrote:

> I didn't realize that morphine is a metabolite of codeine, and  
> therefore the
> mother was not necessarily on morphine too. The news item says  
> codeine and
> morphine were found in baby's blood from toxicology tests. It still  
> does not
> all add up.

Is it alleged that the mother had the genetic variation ("ultrarapid  
metaboliser") in the CYP2D6 enzyme? This can cause serious opioid  
intoxication with just small doses of codeine. Here's another case  
report:

https://content.nejm.org/cgi/content/abstract/351/27/2827

and this bulletin from the Canadian Pharmacists Association discusses  
the issue:

http://www.pharmacists.ca/content/cpjpdfs/nov_dec06/ 
SafetyFirst_Madadi.pdf

Lara Hopkins

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