On 26/7/02 1:05 AM, "Automatic digest processor"
<[log in to unmask]> wrote:

> Every now and then on LACTNET someone will write that ABM impairs gut
> integrity of babies.  I believe this, or at least I would like to believe
> it, because it makes sense.  Problem is, is this really true?

Found some more refs for you:

Go, LL et al. 1994. Breastmilk protects the neonate from bacterial
translocation. J Paed Surgery. 29:1059.
Breastmilk was compared to other feedings using bacterial translocation as a
marker for the permeability of the mucosal barrier. New born rabbits fed
breastmilk had no bacterial translocation to the mesenteric lymph nodes or
liver (although 9% of animals had translocation to the spleen) in contrast
the formula only group  had incidences of 88%, 60% and 32% bacteria spread
in the mesenteri nodes, liver and spleen, respectively.
Stored breastmilk was as effective as fresh breastmilk.

Another study
Okuyama, H et al. 1998. The effect of epidermal growth factor (EDF) on
bacterial translocation in newborn rabbits, J paediatric surgery. 33:225.
Used the same model as above and demonstrated a decrease in formula
associated bacterial translocation by the subcut injection of EGF.
Suggesting EGF may be one of the components in breastmilk giving protection
against permeability. Improved barrier function was associated with an
increase in the number of goblet cells in the mucosa of the intestinal
villi.

Hopes this sheds some light on the issue.

Cathy Fetherston
Perth Western Australia

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