Carla:  Yes, it does have a long half life, but one needs a critical level
to build up; thus, the use of a 400 mg loading dose, with a minimum of 2
weeks daily use of 200mg.  The therapeutic effect is not achieved for quite
some time--many patients need more than a week before they even see any
effect if the yeast is deep in the ducts.  I would strongly stress that they
not go with a once every 36 hours UNLESS the yeasties have been beaten down
and this is a maintence dose at low levels.
Chris>