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Subject:
From:
Fay Bosman <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sat, 26 Oct 2013 13:43:18 -0400
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Hope it's okay to post this on LN. (This is a bona fida organization. We could support it by sharing to help gather a good pool of suitable candidates for the study.)

"We need pregnant women who are planning to breastfeed ANYWHERE in the United States who have NOT been diagnosed with breast cancer to provide breast milk samples for a research study exploring the relationship between pregnancy, breastfeeding, and breast cancer risk."
http://mailing.armyofwomen.org/form/armyofwomen/viewhtml/9z1zck3dageqodqgeni8kkjbqjre7dhkng6gs99b68o

Here is more about the research study itself:
 
Project Title Inflammation Changes Over Time In Obese, Overweight, and Normal Weight Women
Researcher: Edward Sauter, MD, PhD, M.H.A., University of Texas Health Sciences Center in Tyler, Texas at University of Texas Health Sciences Center in Tyler, Texas
Study Abstract: Overview: Inflammation is present in both individuals with cancer and those who are obese. Inflammation is a process critical to the development and progression of breast cancer. Chronic inflammation is a hallmark sign of obesity. Ovarian hormones influence the expression of proteins involved in multiple pathways. 
Hypothesis: Inflammation marker expression will be higher in breast fluid than in the circulating blood; that it will be higher in obese and overweight women compared with normal weight women; and will vary more through the menstrual cycle of premenopausal women compared to postmenopausal women over a 30 day period.
Premenopausal vs. Postmenopausal Participants: A woman’s risk of developing breast cancer increases with increasing age. Postmenopausal participants are at greater risk of having breast cancer than premenopausal participants. Moreover, the risk factors for breast cancer vary based on menopausal status. For example, obesity is a risk factor for postmenopausal breast cancer, whereas most studies do not link the use of exogenous ovarian hormones with increased risk of premenopausal breast cancer. 
Assessment of Inflammation and Cell Proliferation: PGE2. Altering promoter hypermethylation of cyclooxygenase (COX)-2 in cancer cells alter levels of PGE2 and cell proliferation. Increased PGE2 levels are found in a number of inflammatory processes and increases cell proliferation. We have found that PGE2 levels are highly concentrated in NAF compared to matched plasma.

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