Morgan,
Pages 691-693 of Hale 2006
list Paroxetine (trade Name Paxil, Aropax 20, Seroxat)
Paroxetine is a typical SRI. Although it undergoes hepatic metabolism, the
,metabolites are not active. Paroxetine is exceedingly lipophilic and
distributes throughout the body with only 1% remaining in plasma.
It is listed as L2
Pediatric Concerns: Numerous studies suggest minimal to no effect on
breastfed infants. A neonatal withdrawal effect may follow in-utero exposure. Most
studies show minimal to no plasma levels in breastfed infants.
T1/2 = 21 hours
Tmax = 5-8 hours
MW=329
Vd=3-28
M/P=0.056-1.3
PB=95%
Oral = complete
Hope this helps,
Laura Wright
Mississippi
And check out the Medications and Mothers Milk Online or PDA versions -
price is very similar to printed book, and the information says
updated....www.ibreastfeeding.com
In a message dated 7/16/2007 8:02:04 A.M. Central Daylight Time,
[log in to unmask] writes:
Date: Mon, 16 Jul 2007 11:49:21 +0100
From: Morgan Gallagher <[log in to unmask]>
Subject: Depressed and hallucinating mother
I have an asylum seeking mother, severely traumatised by rape, beatings
and torture during pregnancy, that resulted in first born baby dying in
the womb, to be delivered at 28 weeks in hospital.
Currently has a 20 month old, and 6 month old, both breastfed. Mother
is now without any support, and has been suffering severe post traumatic
shock, untreated since original baby's death in 2004. Two weeks ago, a
GP put her on Paroxetine 20 mg daily and told her to stop
breastfeeding. I was contacted yesterday by a supporter, and have
permission to post.
I've had little time to find out much more than that Paroxetine is an
SSRI. Can those with greater medical knowledge than I, check the Hale,
and if this drug is not suitable for breastfeeding, suggest a substitute
that could be used in the circumstances? We can then send her back to
the GP in the first instance and get her baby back onto the breast
before it's too late.
I am, of course, now trying to get her more support, accommodation and
treatment etc.
thanks
Morgan Gallagher
www.nursingmatters.org.uk
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