First, let me thank everyone who responded to my query on oxytocin - I  
haven't even had time to go through the replies, and here I have  
another question already!
I was reading Lawrence and Lawrence today (about oxytocin, of course)  
and stumbled across the section in chapter 8 of the newest edition  
about when babies don't gain "for no apparent reason". One of the  
treatments researched was the administration of TRH, which seemed very  
effective in cases of primary lactational insufficiency (not due to  
any apparent problem with the frequency or mechanics of breastfeeding,  
but a physiological problem with the mom). Apparently the  
adminstration of TRH (Thyrotropin releasing hormone) increased milk  
yield and milk ejection in moms having trouble (and had no effect in  
moms with "full lactation").
So - of course I'm wondering, as we have several moms taking  
domperidone for this very reason, does anyone really use TRH?? Do you  
use it only with a thyroid insufficiency? Are there more risks of side  
effects than with domperidone?
The paper cited in L&L seemed to imply that it was given with  
lactational insufficiency as the only criteria - though I'll need to  
look at it and see if they also tested thyroid levels.
How would this work? General pituitary stimulation enhancing prolactin  
and oxytocin? Another mechanism?
So much physiology, so little time....

Kirsten Berggren, PhD, CLC
www.workandpump.com
and
Lintilhac Breastfeeding Clinic, Williston, VT

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