HI
There is some info on my web page about Domperidone :
http://users.erols.com/cindyrn/reglan.htm

For the purpose of increasing supply, I don't think  it matters about the
timing of it to food.

MMM states that the dosing for increasing supply is 10-20 mg orally 3 - 4
times per day.
Concentrations reported in milk vary according to doe but following a 10 mg
dose three times daily, the avg conc in milk was only 2.6 ug/L

Cindy
~**~**~**~**~**~**~**~**~**~**~**~**~**
Cindy Curtis, RN, IBCLC
mailto:[log in to unmask]
http://www.breastfeedingonline.com


.AU>
> Subject:      Some questions about Domperidone
> --------------------------------------------------------------------------
-----
>
> I've got some questions about Domperidone. My knowledge of pharmacology
> isn't great but I would like to understand the principles involved.
>
> The first question revolves around when Domperidone should be taken. Since
> it is a drug marketed to aid in digestion, package instructions usually
> state that it should be taken 20-30 mins before eating. Is there any
reason
> to take Domperidone at a particular time in relation to eating if it is
> being taken to increase prolactin levels, I've heard that taking it before
> eating increases the absorption of the drug and therefore results in
higher
> prolactin levels than otherwise. Is this the case? What are the mechanisms
> involved in this? I think if taking the drug in relation to eating is
> important that that this is important information that women should have
if
> they are taking Domperidone but if it is tradition/folk lore than we need
to
> know that too. There appears to be some confusion about this and I'd like
to
> understand it myself!
>
> The second question is just how much Domperidone gets into breastmilk when
> the mother is taking it. I know that this would be in MMM but I'm afraid I
> don't have it.
>
> I'd appreciate the assistance of those that have expertise in this area.
>
> Karleen Gribble
> Australia
>
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